Search results for "methods [Neuroimaging]"

The role of fire within Neolithic collective burials: Spatial analyses of cremains from the site of La Truie Pendue, France

2016

International audience; The use of collective graves is one of the main features of the western European Late Neolithic. A single gravesite received the successive deposition of dozens or sometimes hundreds of individuals. While cremations or even full-fired inhumation layers are often found within these funerary deposits, the actual role of fire is still poorly understood. Recently discovered within the important archaeological complex of Passy (Yonne, France), the burned collective grave of La Truie-Pendue provides an outstanding case study to examine the use of fire within Neolithic funerary rites. In this study, we develop a new contextual approach to bone alterations in order to recons…

The effectiveness of compositional animation design: Evidence from eye tracking

2017

Communication donnée le 1er septembre 2017 lors du symposium : Eye tracking as a method in learning and testing with different representations(session L 8); International audience; Learners have difficulty in decomposing conventionally designed animations to obtain raw material suitable for building high quality mental models. A composition approach to designing animations based on the Animation Processing Model was developed as a principled alternative to prevailing approaches. It provides learners with pre-decomposed material that is structured and sequenced to facilitate the relation building required for effective mental model construction. Study of a compositional animation that presen…

Predicting dengue fever outbreaks in French Guiana using climate indicators

2016

Background Dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. Associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. In French Guiana, climate-based models are not available to assist in developing an early warning system. This study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue fever outbreaks in French Guiana. Methodology/Principal Findings Lagged correlations and composite analyses were performed to identify the climatic conditions that characterized a typical e…

Coherence between brain activation and speech envelope at word and sentence levels showed age-related differences in low frequency bands

2021

Abstract Speech perception is dynamic and shows changes across development. In parallel, functional differences in brain development over time have been well documented and these differences may interact with changes in speech perception during infancy and childhood. Further, there is evidence that the two hemispheres contribute unequally to speech segmentation at the sentence and phonemic levels. To disentangle those contributions, we studied the cortical tracking of various sized units of speech that are crucial for spoken language processing in children (4.7–9.3 years old, N = 34) and adults (N = 19). We measured participants’ magnetoencephalogram (MEG) responses to syllables, words, and…

La circulation des objets métalliques à l'âge du Bronze entre Rhône et Saône: utilisation d'une transformation cartographique linéaire

2006

In order to gain a better understanding of circulation flows of metal objects during the Bronze Age, and move beyond traditional distribution maps of archaeological discoveries, the authors propose a more quantitative and concise method of graphic representation, namely cartographic linear transformation. The value of the method was tested on the Saône-Rhône axis. Bronze axes, swords and daggers were recorded along a 50 km strip either side of the river axis, in order to estimate the frequency and mass of objects in “circulation”.

The Rise and Fall of Business Firms: A Stochastic Framework on Innovation, Creative

2021

FPGA implementation of a deep learning algorithm for real-time signal reconstruction in particle detectors under high pile-up conditions

2019

The analog signals generated in the read-out electronics of particle detectors are shaped prior to the digitization in order to improve the signal to noise ratio (SNR). The real amplitude of the analog signal is then obtained using digital filters, which provides information about the energy deposited in the detector. The classical digital filters have a good performance in ideal situations with Gaussian electronic noise and no pulse shape distortion. However, high-energy particle colliders, such as the Large Hadron Collider (LHC) at CERN, can produce multiple simultaneous events, which produce signal pileup. The performance of classical digital filters deteriorates in these conditions sinc…

Devenir chercheur ou enseignant chercheur : le goût pour la recherche des doctorants à l'épreuve du marché du travail

2016

Faire une thèse pour devenir chercheur ou enseignant-chercheur est souvent considéré comme un parcours difficile dont le résultat est incertain. Plus que dans d’autres pays, les diplômés de doctorat en France connaissent de fortes difficultés de stabilisation sur le marché du travail. Notre recherche s’interroge sur les raisons qui conduisent les jeunes à obtenir un doctorat puis à choisir une carrière de chercheur ou d’enseignant-chercheur et enfin, à s’y stabiliser. À partir d’une enquête du Céreq, nos résultats montrent que l’intérêt pour la recherche qu’ils ont manifesté dès le début des études supérieures et le capital social vont fortement structurer leur parcours universitaire et pro…

Absolute and relative quantification of RNA modifications via biosynthetic isotopomers

2014

In the resurging field of RNA modifications, quantification is a bottleneck blocking many exciting avenues. With currently over 150 known nucleoside alterations, detection and quantification methods must encompass multiple modifications for a comprehensive profile. LC-MS/MS approaches offer a perspective for comprehensive parallel quantification of all the various modifications found in total RNA of a given organism. By feeding (13)C-glucose as sole carbon source, we have generated a stable isotope-labeled internal standard (SIL-IS) for bacterial RNA, which facilitates relative comparison of all modifications. While conventional SIL-IS approaches require the chemical synthesis of single mod…

Computational identification of cell-specific variable regions in ChIP-seq data.

2019

ABSTRACT Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is used to identify genome-wide DNA regions bound by proteins. Several sources of variation can affect the reproducibility of a particular ChIP-seq assay, which can lead to a misinterpretation of where the protein under investigation binds to the genome in a particular cell type. Given one ChIP-seq experiment with replicates, binding sites not observed in all the replicates will usually be interpreted as noise and discarded. However, the recent discovery of high-occupancy target (HOT) regions suggests that there are regions where binding of multiple transcription factors can be identified. To investigate these regions,…